The remarkable paradigm of segmental (mosaic) drug eruptions

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Drug eruptions.

The last four decades have seen an enormous increase in the use of potent and toxic drugs as therapy. The considerable advances that these drugs have provided in the control and prevention of disease are matched by their potential to produce unwanted side effects many of which are reflected in the skin. These side effects cannot in the main be predicted. Tests in animals may not reliably be ext...

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Drug-Induced Acneiform Eruptions

Acne vulgaris is a chronic skin disease that develops as a result of inflammation of the pilosebaceous unit and its clinical course is accompanied by comedones, papules, pustules, and nodules. A different group of disease, which is clinically similar to acne vulgaris but with a different etiopathogenesis, is called “acneiform eruptions.” In clinical practice, acneiform eruptions are generally t...

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Cutaneous drug eruptions.

Patients attending a referral Skin Clinic were studied to identify the spectrum of drug eruptions and the offending drugs. There were 51 patients with an incidence of five per thousand and equal sex incidence. Though the pattern of eruption was broadly similar to other reports, unusual reactions were observed. In addition to the skin manifestation, fever and lymphadenopathy were present in most...

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Eosinophils in Drug Eruptions

Background: Previous studies indicated that eosinophils infi ltrate the skin during drug eruptions and that counts may become elevated in circulation. However, little is known about the role of eosinophils in the prognosis of patients with drug eruption. Objective: This study aims to investigate the correlation between circulating eosinophil counts and the prognosis of patients with drug erupti...

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Genital fixed drug eruptions.

Twenty nine patients with genital fixed drug eruptions were studied during one year. In 15 the genitalia were exclusively affected, whereas the other 14 had cutaneous lesions in addition. It was striking that those whose lesions were exclusively genital reported for consultation much earlier. Drug history was the mainstay of diagnosis. Provocation tests with graded doses of the suspected drug(s...

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ژورنال

عنوان ژورنال: Indian Journal of Dermatology

سال: 2012

ISSN: 0019-5154

DOI: 10.4103/0019-5154.103075